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After 12 weeks, when the subjects were examined, the group presented with the minor concentration appeared to exhibit the highest reduction in subject body weight (up to an average of 2.8 kilograms)

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The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

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This includes individuals with severe anxiety or other psychological disorders, thyroid dysfunction, cardiovascular disease, and those who are pregnant or breastfeeding