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As expected, our results demonstrated that tumor primary cultures obtained after chemotherapy exhibited significantly higher resistance to cisplatin compared to their chemotherapy-naive counterparts (Fig

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E2 withdrawal suppresses sirtuin 1-mediated deacetylation of key metabolic enzymes, resulting in downregulation of IDH 3 (IDH3) and -KGDH, both rate-limiting enzymes in the TCA cycle (124,125)

MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells

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Allergy 63: 11561163 Acknowledgements The study was funded by the Deutsche Forschungsgemeinschaft (DFG) grants SCHO817/33, SFB1039 (TP A08) and GRK2336 (TP07) as well as the LOEWE initiative ACLFI (P02) and the Fraunhofer Cluster of Excellence for ImmuneMediated Diseases (CIMD), Frankfurt/Main