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As GLP-1 receptor agonists continue to be widely adopted for obesity and metabolic disease, it is essential to consider their broader implications for bone health and orthopedic surgery
It precedes more serious bleeding events by days to weeks
Excellent experience
Harder to benchmark: when results change, you cannot isolate which peptide contributed to the outcome
They are activated by cAMP and may be regulated by phosphorylation catalyzed by protein kinase A and C (PKA and PKC), and require the binding and hydrolysis of ATP to open the channel [100,116]
Inhibition of Lipogenesis (The Pull): It inhibits Lipoprotein Lipase (LPL) and Acetyl-CoA Carboxylase (ACC), preventing the uptake of dietary fat and the synthesis of new triglycerides
