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Importantly, gastrointestinal involvement has been linked to reduced responsiveness to IVIg therapy, suggesting that gut-derived immune alterations may influence treatment outcomes (55)

To clarify gut microbiota interventions' efficacy in alleviating depressive symptoms, researchers did systematic reviews and meta-analyses, including RCT on probiotics, prebiotics, synbiotics or fecal microbiota transplantation in adults (18 years) that used validated, placebo-controlled measures to assess depressive symptoms

Despite its safety, there is an important caveat for the chronic illness community known as the "sulfur paradox." While MSM is incredibly beneficial for clearing histamine and reducing inflammation, a specific subset of patients may experience severe adverse reactions