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Acknowledgements We apologize to all the scientists whose work could not be discussed in the pages of this review

Multiphoton microscopy (MPM) as described by Zipfel, Williams, & Webb [239] is a minimally-invasive method of in vivo fluorescent imaging that can be used to study solute transport to the growth plate of live anesthetized animals at cellular-level resolution [238]

Glial activation and neuroinflammation have been shown to be prominent features of AD pathology (Newcombe et al., 2018

Such procedures require trained personnel, sterile phlebotomy equipment, and dedicated infrastructure, limiting their suitability for frequent or near-patient monitoring [58]

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