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For instance, in NSCLC cells, elevated lactylation of histone H3 reduces glycolysis and maintains mitochondrial balance by altering mRNA levels of glycolytic enzymes ( HK1, PKM ) and TCA cycle enzymes ( SDHA, IDH3G ), highlighting the crosstalk between histone Kla and glucose metabolism in cancer progression

[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Kim JH, Lewin TM, Coleman RA

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Notably, the addition of carnitine or knockdown of TMLHE did not have marked effects on histone methylation (Extended Data Fig

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