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This effect profile has been studied in primates and, to a more limited degree, in humans, though as with the telomerase data independent replication outside the original research program remains limited

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113 It was then fused to the constant region (Fc) of modified human immunoglobulin G4 (IgG4) via a -(Gly-Gly-Gly-Gly-Ser) 3-Ala- bridge and exhibits an average biological half-life of 90 h

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