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Potential therapeutic applications of catalase mimics As discussed above, hydrogen peroxide is formed from superoxide radical anions either spontaneously or by rapid enzymatic (SOD) dismutation

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2 Animal models for CIPN studies Animal models are frequently used to study the pathogenesis of CIPN and more importantly, to evaluate the drug efficacy in preventing or reversing CIPN symptoms (Hoke and Ray, 2014)

Sample sizes were chosen based on existing literature in the field for similar experiments 39,43

Bruner SD Structural Basis for Precursor ProteinDirected Ribosomal Peptide Macrocyclization

This body of research spans gastric ulcer models, inflammatory bowel disease, intestinal fistulas, and surgical anastomosis healing making the GI tract the single most extensively studied area in BPC-157 literature