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Furthermore, the fraction of oral vitamin C that is not absorbed passes into the large intestine where it draws in water and can cause loose stools the familiar gastrointestinal side effect of high-dose oral supplementation

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Finkelstein JL, Layden AJ, Stover PJ

Non-viral vectors are protein complexes which have lower gene expression and limited effectiveness as compared to viral vectors because they are not incorporated into the cells genome and are susceptible to degradation