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Consistent with the proteomic findings, key metabolites linked to cysteine and glutathione including s-adenosylmethionine (SAM), glutathione (GSH), glutathione oxidized (GSSG), and -Glutamylcysteine (gamma-Glu-Cys) [25] were markedly reduced in shDDX3X cells (Fig

doi: 10.1371/journal.pone.0065535

A recent study also showed that some of pentapeptide non-existing proteins may create a KFERQ-like structure for HSC70 recognition in cells under oxidative stress [106]

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58,59,60 SPD and SPM are involved in various cellular processes, such as the regulation of autophagy pathways, mTOR signaling, and oxidative stress and antioxidant pathways