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Both fusion and fission are required to fine-tune fundamental cellular processes such as the generation of ATP and reactive oxygen species, ROS

doi: 10.1007/s12471-020-01505-y 19 LomeroMGardinerDCollEHaase-KromwijkBProcaccioFImmerFet al

Pathological alterations in gut microbiota induce the increased production of toxic metabolites and reduced production of beneficial compounds like short-chain fatty acids

When glutathione production drops, you are more vulnerable to: autoimmune disease chemical sensitivities heavy metal sensitivities inflammatory disorders intestinal permeability (leaky gut) other immune issues Stress lowers glutathione levels When we are healthy, our bodies make enough glutathione to protect us

Against this background, the concept of PANoptosisdefined as the simultaneous activation of pyroptosis, apoptosis, and necroptosishas gained attention