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The more direct published evidence currently available concerns VEGFR2 expression, VEGFR2-Akt-eNOS signaling, and Src-Cav-1-eNOS pathway activation rather than the complete transcriptional-to-secretory VEGF sequence

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The exact cause of IBS is not fully understood, but it is believed to involve a combination of gut motility issues, inflammation, and sensitivity to various triggers
