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Direct, continuous effects are not well established in humans

Disc diffusion assay for AmGSTO1

YangWSSriRamaratnamRWelschMEShimadaKSkoutaRViswanathanVSet al

Therefore, comprehending how the DTP cells arise mechanistically is crucial for the ultimate goal of reversing the DTP cells for therapeutic purposes

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However, under defined pathophysiological stresses, including inflammatory cues, metal overload, cysteine deprivation, or drug exposure, GSH oxidation and thiol chemistry may become coupled to metal redox cycling and mitochondrial damage amplification, thereby increasing susceptibility to forms of regulated cell death such as ferroptosis and cuproptosis