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First, pathway complexity raises on- and off-target risks when modulating ASC, caspase-1, GSDMD, IL-1, NF-B, P2X7R, IKK, FTH1, ACSL4, miR-204, or GPX4, and microglia-specific target engagement is difficult to confirm

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Nehal, Ibrahim Ashaimaa Y., Moussa (2020) Comparative metabolite profiling of Callistemon macropunctatus and Callistemon subulatus volatiles from different geographical origins Industrial Crops and Products 147112222-10.1016/j.indcrop.2020.112222 Funding Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB)

These metabolites also serve as energy sources, key activity regulators, signal transducers, electron donors and buffers of both pH and osmotic pressure