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We constructed standardized experimental models encompassing murine full-thickness burn injuries [13], rat dermal incisional wounds [13], and rodent skeletal muscle contusion models (Figure S1)

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H2 blockers like ranitidine have similar but less severe effects

Notably, a golden standard to assess preclinical CLBP is still missing but is urgently needed to substantiate therapeutic efficacy of novel biomolecular therapies for CDLBP

Thanks to my really helpful GP she also investigated why the fatigue hadnt eased as expected and found I also had a heart condition

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