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For example, a previous study on PD brains showed an increase in lipid peroxidation products, such as 4-hydroxinonenal, and in protein crosslinking and fragmentation [51], suggesting that oxidative stress may affect other brain regions apart from the SN
However, in Lear and Castle's study of pernicious anemia patients in remission, the depletion of serum vitamin B-12 after treatment with folic acid occurred in the absence of any noticeable change in hematopoiesis (Figure 9) (52)

CopperTreatment Increases the Cellular GSH Content and Accelerates GSH Export From Cultured Rat Astrocytes. Neuroscience Letters 498: 4246

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