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& VanHouten, B

Generally, oral administration is recognized as the easiest and most convenient way

The mechanism of medicinal plants is broad, and includes regulation of intestinal microbiota composition and intestinal permeability, increased expression of both mRNA and claudin-1 protein, and anti-inflammatory effects (Chinese tea, hibiscus, liquorice, marshmallow, ginger root, peppermint, plantain, curcumin)

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AA147-dependent ATF6 activation only modestly contributes to protection against glutamate-induced toxicity observed in HT22 cells AA147 protects cardiomyocytes from oxidative insults through activation of ATF6 (14)

In addition, icaritin upregulates CXC chemokines (e.g., CXCL9 and CXCL10) and T cell marker factors (e.g., CD8 and IFN- ), facilitating the recruitment of immune cells to tumors, and formed a "hot" tumor microenvironment in lung cancer (Lewis) cells [713]