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Therapeutic Research Protocol Dose: 0.5 0.9 mg (= 1018 clicks) Duration: 3 4 weeks Frequency: 2 daily, divided doses Cycle Interval: 4 weeks off before repeating Goal / Description: Higher-dose protocol used in stress-response and GABAergic modulation studies

2022;29(5):799810.e4

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Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)

Dimitriadis et al., Malone et al