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Complications of Uremia: Skin changes, such as darker color Intense itching Inflammation of the sac-like covering around the heart Fluid build-up around the heart Fluid in the lungs Heart valve hardening Brain dysfunction related to uremia Imbalance of bodily salts Heart disease Inflammation of the pancreas associated with uremia Preventing Uremia Patients should avoid medications that can hurt the kidneys, such as aminoglycoside antibiotics (a type of antibiotic), NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) and other substances that can harm the kidneys