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It just needs a structured way to answer it

The lack of adequate cobalamin in the body hinders the regeneration of tetrahydrofolate, which eventually leads to megaloblastic anemia due to the functional folate deficiency.910 On the other hand, the methylmalonyl-CoA mutase helps to metabolize odd chain fatty acids and branch chain amino acids.5 Cobalamin is also thought to keep the bodys level of sulfhydryl (SH) groups in reduced form

However, this synergistic effect does not appear to be strictly required for the reaction to occur

For instance, epigenetic alterations such as DNA methylation and histone modification can lead to the silencing of tumor suppressor genes, thereby facilitating the development of chemoresistance

It is important to approach these reviews with realistic expectations

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