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More interestingly, exogenous copper can promote ferroptotic cell death, but not Cuproptosis, by directly binding to GPX4 and further increasing GPX4 degradation [176]

Stem cell fate in cancer growth, progression and therapy resistance

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Upon ligand binding, TLRs recruit adaptor proteins primarily MyD88 or TRIF which activate downstream kinases including IRAKs and TRAF6, leading to the stimulation of transcription factors NF-B, AP-1, and IRF family members [33]

This SCLC-specific feature of NE-non-NE plasticity may explain why, so far, the in vivo combination of BSO with Auranofin and Carboplatin has only achieved very limited efficacy in lung adenocarcinoma, which is not characterized by NE/non-NE plasticity 66

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