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Older adults, who often suffer from decreased hydrochloric acid in the stomach, and individuals with gastrointestinal (GI) disorders may have lower absorption of B12.2,4 Vitamin B12 deficiency may be characterized by megaloblastic anemia, fatigue, weakness, constipation, loss of appetite, soreness of the mouth or tongue, and weight loss

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10.1038/35030000 38 Coutos-ThevenotP.MaesO.JouenneT.Claude MauroM.BoulayM.DeloireA.et al