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When saturation occurs, excess acetaminophen is diverted through CYP2E1, producing the hepatotoxic metabolite NAPQI (N-acetyl-p-benzoquinone imine)
The findings of the present study confirmed the results of previous studies
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Further, substitution of Arg for Sec may not be a random amino acid insertion, as two of the six Arg codons (CGA and AGA) have only a single base difference with the UGA codon
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10.1093/nar/gkv1070 43 KarabulutD.OzturkE.KulogluN.AkinA
