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Among 17-year-olds, in 2022, lifetime use of MDMA/ecstasy stood at 2.0%, decreasing in comparison with 2017, where it affected 3.4% of these adolescents

Sometimes, estrogen therapy is used to help with fertility

Longer continuous use (months) departs from the cycling framework and has no specific evidence base

doi: 10.1080/09546630802178232

doi: 10.1158/0008-5472.CAN-09-2609
