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This dual role of mtDNA, initiator of acute responses and perpetuator of chronic inflammation, links metabolic distress to progressive neuronal injury in aging and NDDs

HUBERMAN: Need to be considered in light of the fact that they cause big increases in cortisol

Additionally, excessive Mn has been linked to metabolic disorders, including type II diabetes, obesity, and cardiovascular disease, with oxidative stress proposed as a key contributing factor (Li and Yang, 2018)