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(I've described my distaste for the entire concept of antidotes in a previous column, arguing that the term leads to muddy thinking and failure to weigh critically whether or not a specific intervention is indicated in individual cases.) Dr Juurlink is careful to point out that the vast majority of VPA overdose cases will not need a carbapenem because most patients improve with routine treatment

It is also possible that HPA sensitivity rather than HPA axis dysfunction exists in patients (63)

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Thus, understanding the interplay between bioaccessibility and bioavailability is essential for selecting appropriate intake levels and optimizing processing or cooking methods to enhance the physiological benefits of dietary phenolics (Gutirrez-Grijalva et al., 2016