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Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma

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Introduction Glutathione (GSH), or l--glutamyl-l-cysteinyl-glycine, is a tripeptide present in mammalian cells at surprisingly high levels (110 mM) and particularly concentrated in the liver [1,2]

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