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+ - These drugs, such as agomelatine and GW117, are designed as MT1/MT2 agonists combined with 5-HT2C receptor antagonists

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Vitamin C stimulates the degradation of cholesterol by the activation of hepatic microsomal cytochrome P-450-dependent enzyme, cholesterol-7-a-hydroxylase, the rate limiting enzyme in the catabolism of cholesterol to bile acids (Ginter 1975, Bjorkhem and Kallner 1976)

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