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This process can be initiated by iron-catalyzed Fenton chemistry, in which hydroxyl radicals (OH) generated from H 2 O 2 trigger a self-propagating lipid peroxidation chain reaction

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Various studies using this approach have reported a substantial reduction in early and late-stage irradiation damage following the delivery of magnesium superoxide dismutase (MnSOD) transgenes systemically or in a tissue-specific manner by using plasmid/liposomal vectors (175, 176)