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Compared with other Teff cells, Th17 cells present high glycolytic metabolism, which significantly promotes iron death-related metabolic changes, such as increased ROS production and increased synthesis of PUFAs, which are positively correlated with the differentiation trends of each Teff cell type

Nonetheless, their limited payload capacity restricts the delivery of large CRISPR-dCas9 effector proteins [320]

Both hypo-methylation and hyper-methylation of DNA have been observed within cancer cells

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The gut microbiome composition, measured by 16S rDNA sequencing, showed no difference in both alpha and beta diversities, whereas the LEfse analysis revealed a microbial shift after the treatment, with a decreased abundance of the genus Ruminococcus from the Lachnospiraceae family ( p = 0.009), and the unclassified genus from the family Erysipelotrichaceae (UC36, p = 0.003) in the FVS group compared with the PLA group (confirmed by SIAMCAT analysis, AUC = 74.1%)