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These studies are incredibly promising but are not a substitute for human trials
TDRG1 functions in testicular seminoma are dependent on the PI3K/Akt/mTOR signaling pathway
among those, GTPases or their activators/inhibitors (Tiam-1 - T-cell lymphoma invasion and metastasis-inducing protein 1, Rho-C - Ras homolog gene family, member C), and receptor tyrosine kinase (RTK) upstream of Rho GTPases as hepatocyte growth factor receptor (HGFR/c-Met) or tyrosine kinase receptor (Trk-A) [22]
Placebo treated subjects did not exhibit any binding
