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This helps explain why many patients report feeling full sooner and staying satisfied longer

In addition to pain, symptoms include a tingling or burning sensation, numbness, and muscle weakness

International Journal of Medical Sciences 17 (6): 751761

Interestingly, in chronically insulin treated 3T3-L1 cells and fat explants from insulin resistant mice, only insulin-stimulated glucose uptake is decreased while insulin suppression of lipolysis is intact (121), effects which are explained by selective insulin resistance in adipocytes

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This means subcutaneous injections are often used when other administration methods might be less effective