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138 Simultaneously, SIRT3 can not only induce the expression of antioxidant enzymes by activating the FOXO3a, but also enhance the activation of SOD2 and catalase via NAD + -dependent deacetylation

The neuroprotective effects come through multiple pathways: inhibition of nitric oxide synthesis under ischemic conditions, antioxidant activity, protection against glutamate neurotoxicity, and mitochondrial stabilization under calcium dysregulation

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Additionally, MC-LR activates the protein CaMKII, which escalates oxidative stress and cell death processes, while also influencing proteins like Nek2 and P53, which are linked to cell growth and tumor suppression

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