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If you are having side effects at your current dose, do not increase your dosage until those side effects have resolved

When you will notice changes

If you cannot confirm when it was opened, treat it as expired

(Surely it goes without saying that if someone choosing a vegan diet is seriously ill due to lack of B12 they they should not be denied the right to injections in order to facilitate a swift recovery)

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Systematic capture of dosing patterns, formulation source, route of administration, and standardized clinical outcomes may be more informative than continued reliance on heterogeneous mechanistic studies