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The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

options include high-dose oral cyanocobalamin (1,000 mcg daily) or intramuscular hydroxocobalamin injections, with IM injections preferred for confirmed deficiency or neurological symptoms

For individuals with conditions that affect B12 absorption, such as pernicious anemia or gastrointestinal disorders, monitoring helps to track the progression of the disease and the effectiveness of treatment

J.et al (2016)