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Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents

The future of nanoremediation must be guided by a proactive, integrated, and systems-level approach. Embracing safe-and-sustainable-by-design (SSbD): as argued in section 5.5, the SSbD paradigm must become the guiding principle of the field.187 This involves embedding safety and sustainability assessments into the earliest stages of material design, with a focus on mechanistic decoupling (preserving efficacy while minimising hazard) and designing for a benign fate (e.g., controlled dissolution into non-toxic components)

1 Beta-glucans derived from reishi and other mushrooms have been found to inhibit the proliferation of certain breast cancer lines through the induction of apoptosis and cell-cycle arrest, and meta-analyses have found an inverse relationship between eating mushrooms and breast cancer

Understanding the differences between these compounds is essential from a product development perspective

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Genetic variability related to serum uric acid concentration and risk of Parkinsons disease