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They also reported that these patients had higher levels of interleukin 1 (IL-1), IL-6, and TNF- , suggesting an inflammatory state and oxidative stress in migraine patients (112)

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This raises the notion that perhaps within konzo-prone regions of sub-Saharan Africa there may be genetic variants of GPx3, or genes related to associated pathways that circulate which could alter gene expression and subsequently cause a reduction of protein abundances in these populations

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