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Moreover, a significant increase in human mortality has occurred, for the past few decades, due to the increased prevalence of diet-induced obesity and chronic disorders like non-alcoholic fatty liver disease, type 2 diabetes, cancer, atherosclerosis and coronary heart disease

doi: 10.2353/ajpath.2009.080596 86

Lei P, Ayton S, Bush AI (2019) Axonal dispatch of iron in neuronal signaling

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A self-perpetuating cycle of ROS production and oxidative stress is particularly evident in AD and PD, where mitochondrial dysfunction, characterized by deficits in respiratory chain complexes, altered mitochondrial morphology, and impaired mitophagy, is well documented [56,212]