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Unfortunately, especially in young people, symptoms only become apparent after the disease has reached an advanced stage

Intermittent claudication (IC) is the predominant symptom of PAD, but only about 10% of patients with PAD experience ICand are associated with reduced exercise capacity

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In juvenile rats, a decrease in testes weight was only observed at doses exceeding the maximum tolerated dose (from 240 mg/kg/day by intraperitoneal or intravenous route) and with no associated histopathological changes