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In contrast to findings in the APPROACH and COMPASS trials, volanesorsen or olezarsen ASO treatment did not significantly alter plasma LDL-cholesterol concentration in patients with mild-to-moderate HTG [81, 88]

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Vasc.Med 2012;17(3):145-154

These proteins attach via hydrogen bonds and weak electrostatic interactions to hydrophilic phospholipid heads and hydrophilic regions of integral membrane proteins ( Figure 5.7 ) Lipid-anchored membrane proteins also lack hydrophobic regions on their surface, so they attach to the membrane via covalent bonds to lipids which are embedded in the membrane

This remains an area for ongoing evaluation and underscores the need for careful consideration in future updates to clinical practice guidelines
