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Spontaneously hypertensive rats (SHRs) exhibit elevated renal expression of NADPH oxidases and biomarkers, such as NGAL, which correlates with histological findings of glomerulosclerosis and tubulointerstitial fibrosis [60]

These oxidative thiol modifications are fully reversible, and their reduction is mediated by thiol-based redox systems, most prominently the glutathione (GSH)/glutathione reductase (GR) and thioredoxin (Trx)/thioredoxin reductase (TrxR) system

Sumi H, Hamada H, Nakanishi K, Hiratani H

The most common type of liver failure develops after many years of damage from chronic liver disease

& Meyer, A

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