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Its reduced IGFBP affinity allows more free ligand to engage receptors directly, enabling extended pathway observation without the binding-protein interference encountered with native IGF-1

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Maternal diabetes induces autism-like behavior by hyperglycemia-mediated persistent oxidative stress and suppression of superoxide dismutase 2

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Hu Y., Zhang M., Yang T., Mo Z., Wei G., Jing R., Zhao H., Chen R., Zu C., Gu T., Xiao P., Hong R., Feng J., Fu S., Kong D., Xu H., Cui J., Huang S., Liang B., Yuan X., Cui Q., Guo H., Yu Y., Feng Y., Jin C., Ren J., Chang A.H., Wang D., Huang H

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Mittal (55) and others compared mice with overexpression or knockout of the TWEAK gene and found that skeletal muscle atrophy and fast muscle fibers increased significantly after 4 to 5 months of overexpression, with increased Fn14 expression level and the opposite finding in the knockout group