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Discussion In this study, we demonstrated that OA mice exhibit a lower level of H 2 S in synovial fluid and plasma compared with SHAM mice in vivo and GYY4137 can effectively suppress DMM-induced synovial macrophage pyroptosis and cartilage degeneration

This process is readily triggered by specific dietary compounds

Histone methyltransferases: novel targets for tumor and developmental defects

One 12-week randomized clinical trial found that subjects receiving 1mg daily lost an average of 2.6kg compared to 0.8kg in the placebo group

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Wu et al., using a CLP sepsis mouse model, reported that autophagy inhibition with 3-MA led to decreased Beclin1 and LC3-II/I levels but caused p62 accumulation and worsened renal damage (74)