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Reactive astrocytes switch their metabolism under disease conditions Astrocyte metabolism undergoes significant alterations during aging and neurodegenerative diseases, contributing to disease progression and exacerbating neuronal dysfunction

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Under standard conditions, HIF is posttranslationally hydroxylated at two conserved proline residues by the prolyl4hydroxylase enzymes (PHD13), leading to interaction with the von Hippel-Lindau (VHL) protein, polyubiquitination and proteasomal degradation

For these reasons, BPC-157 is supplied strictly as a research-use-only reference compound

Immunology Letters,NagaseM.ShiotaT.TsushimaA.MurshedulM.FukuokaS.YoshizawaT.SakatoN.2002 156