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Limitations and lack of clinical data Sublingual delivery sounds promising, but several limitations exist to think about when comparing liposomal vs sublingual NAD+: Your saliva naturally dilutes and washes away some NAD+ before it fully penetrates the sublingual tissue, leading to incomplete absorption

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Umeoguaju et al

This could limit the efficacy of nitrate supplementation, because RONS such as superoxide (O 2 -) directly react with NO, diminishing its bioavailability [85]

Gene overexpression and knock-down studies have demonstrated a strong association between increased CYP2E1 activity and alcohol-induced fatty liver 35,36