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Among mucin subtypes, overexpression of MUC5AC alone does not cause airway obstruction or inflammation, as MCC is preserved

T2D: type 2 diabetes

Research by Hayakawa et al

APOE4 and Synaptic Plasticity in the Pathogenesis of AD Interneuronal communication is one of the major functional features of the human brain, and this communication proceeds via synapses

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Therefore, it would not be wrong to assume that the resulting phenotype can be attributed to the combined effect of altering the specific coding gene as well as the other non-coding genes that get affected inadvertently due to the disruption by genetic engineering method used to generate the knockout organism