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In this regard, Yu et al

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doi: 10.1016/j.biopha.2021.111798 27 AugustinRCDelgoffeGMNajjarYG

They generally interact with key glands: the hypothalamus, pituitary, thyroid, adrenals, ovaries, and testes either through direct binding or through influencing upstream signals

Using marker substrates to identify induction of specific P450s, Kreuger and coworkers provided a summary of sex and species differences in the magnitude of CYP enzyme induction
