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Cryo EM dynamics analysis and post-3D classification of CTR:Cagri/CagriBB complex 3D variability analysis (3DVA) implemented in cryoSPARC v4.4.1 29,39 was performed to interrogate and visualize the dynamics in the complexes as previously described 25

- when there is risk of torsades de pointes, for example in patients with prolonged QT, concomitant administration of other medications that produce torsades de pointes (amiodarone, quinidine, bepridil, IV erythromycin, halofrantine, pentamidine, sparfloxacin, sultopride, vincamine, betrilio, disopyramide, sotalol, etc)

however, these observations remain preliminary and require prospective confirmation [58,59]

13 The relatively high redox potential of the Cu 2+/ Cu + system is utilized for oxidation reactions, such as the generation of superoxide by superoxide dismutase (SOD) and catechols by tyrosinase