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Optimization of these technological challenges, including means to either mechanically or biologically bypass the BBB, achieve sufficient antibody levels in CNS to enable adequate target engagement, and direct elimination only against aggregated -syn species, are needed to further evaluate important implications for future therapeutics

In Eskin NA (ed.)

Notably, several uremic solutes have also been implicated in systemic endothelial dysfunction and microvascular injury, suggesting a link to the proteinuriarelated cerebrovascular changes observed in epidemiological PD studies [145]

Regionally specific susceptibility may be due to the proximity of the medial rostral corpus callosum to the subventricular zone, as neural precursor cells from the subventricular zone migrate into the proximal rostral corpus callosum by week 3 of cuprizone administration, where they can dampen the inflammatory response and differentiate into mature oligodendrocytes 26,51,52,53

Mirkazemi C, Peterson GM, Tenni PC, Jackson SL

Differences in total reduced GSH were: 74.5294.8 mol/L versus 34.5334.7 mol/L for the GSH group and the placebo group, respectively ( p =0.67 between groups)