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The discrepancy over time gets doubled in the differences

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For instance, two siblings both harboring the same mitochondrial mutation causing Lebers hereditary optic neuropathy had markedly different clinical courses: the brother exhibited typical progressive optic neuropathy whereas the sister suffered from a relapsingremitting MS-like illness (Joshi and Kermode, 2019)

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Many of these data were collected over months, and some over almost three years

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